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Hematological changes in opium addicted diabetic rats
Gholamreza Asadikaram1, Majid Sirati-Sabet2, Majid Asiabanha2
1Department of Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IR Iran ; Physiology Research Center, Kerman University of Medical Sciences, Kerman, IR Iran.
International Journal of High Risk Behaviors & Addiction
|June 28, 2014
Summary
Opium addiction significantly alters blood cell counts in diabetic rats, with distinct effects observed in males and females. This may increase infection risk due to immune system imbalance.
Area of Science:
- Hematology
- Toxicology
- Endocrinology
Background:
- Chronic opioid use in animal models is known to affect hematological parameters.
- Opium's impact on blood cell profiles, particularly in diabetic individuals, requires further investigation.
Purpose of the Study:
- To investigate the effects of opium addiction on peripheral blood cell counts and red blood cell (RBC) indices in diabetic rats.
- To compare these effects between male and female diabetic rats with and without opium addiction.
Main Methods:
- Hematological parameters were measured in peripheral blood samples from four groups of male and female rats: normal, diabetic, opium-addicted, and diabetic opium-addicted.
- Key parameters assessed included white blood cells (WBCs), red blood cells (RBCs), and platelets.
Main Results:
- Diabetic opium-addicted females showed significantly higher white blood cell (WBC) counts than diabetic non-addicted females.
- Neutrophil counts increased, while lymphocyte counts decreased in diabetic opium-addicted rats (both sexes) compared to diabetic non-addicted rats.
- Red blood cell (RBC) counts increased in diabetic opium-addicted males but decreased in diabetic opium-addicted females.
- Platelet counts were significantly lower in diabetic opium-addicted rats of both sexes compared to their diabetic non-addicted counterparts.
Conclusions:
- Opium addiction exerts differential effects on white blood cell (WBC), red blood cell (RBC), and RBC indices in male and female diabetic rats.
- Opium addiction may heighten the risk of infection in addicts due to an impaired immune system resulting from opium's imbalancing effects on immune cells.
