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Updated: Apr 27, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
An association study between genetic polymorphism in the interleukin-6 receptor gene and coronary heart disease
Jiangqing Zhou1, Xiaoliang Chen2, Huadan Ye3
1Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China.
Abstract:
The goal of our study is to test the association of IL6R rs7529229 polymorphism with CHD through a case-control study in Han Chinese population and a meta-analysis. Our result showed there is a lack of association between IL6R rs7529229 polymorphism and CHD on both genotype and allele levels in Han Chinese (P > 0.05). However, a meta-analysis among 11678 cases and 12861 controls showed that rs7529229-C allele was significantly associated with a decreased risk of CHD, especially in Europeans (P < 0.0001, odds ratio = 0.93, 95% confidential interval = 0.89-0.96). Since there is significant difference among different populations, further studies are warranted to test the contribution of rs7529229 to CHD in other ethnic populations.
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