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Current therapeutic options in hairy cell leukemia
Evgeny Mikler1, John Mascarenhas
1Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA
The Journal of Community and Supportive Oncology
|June 28, 2014
Summary
Hairy cell leukemia (HCL) is a B-cell cancer requiring treatment for symptomatic patients. Advances have improved diagnosis and management, with options including chemotherapy, immunotherapy, and surgery.
Area of Science:
- Hematology
- Oncology
Background:
- Hairy cell leukemia (HCL) is a rare B-cell chronic lymphoproliferative disorder.
- It presents with monocytopenia, organomegaly, constitutional symptoms, and bone marrow fibrosis.
Purpose of the Study:
- To summarize the diagnostic and management advances in HCL over the past 55 years.
- To outline the indications for treatment and available therapeutic options.
Main Methods:
- Review of literature on Hairy cell leukemia diagnosis and treatment.
- Analysis of clinical characteristics and therapeutic outcomes.
Main Results:
- Significant progress has been made in HCL diagnosis and management.
- Treatment is indicated for symptomatic patients or those with bone marrow failure or infections.
- Asymptomatic patients without cytopenias may be observed.
Conclusions:
- Hairy cell leukemia, while indolent, often requires intervention.
- Therapeutic strategies encompass chemotherapy, immunotherapy, biological agents, and surgery.
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