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Updated: Apr 27, 2026

Measuring Associative Learning in Chemotaxis of the Nematode Caenorhabditis elegans
Published on: June 17, 2025
Functional neuromodulation of chemosensation in vertebrates
Christiane Linster1, Alfredo Fontanini2
1Computational Physiology Lab, Department of Neurobiology and Behavior, Mudd Hall W249, Cornell University, Ithaca, NY 14853, USA.
Abstract:
Neuromodulation can be defined as a biophysical process that serves to modify-or modulate-the computation performed by a neuron or network as a function of task demands and behavioral state of the animal. These modulatory effects often involve substances extrinsic to the network under observation, such as acetylcholine (ACh), norepinephrine (NE), histamine, serotonin (5-HT), dopamine (DA), and a variety of neuropeptides. Olfactory and gustatory processes especially need to be adaptive and respond flexibly to changing environments, availability of resources and physiological needs. It is therefore crucial to understand the neuromodulatory processes that regulate the function of these systems.
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