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Recovery from SIADH-associated osteoporosis: a case report.
Anne-Sophie Sejling1, Anne-Luise Thorsteinsson, Ulrik Pedersen-Bjergaard
1Department of Cardiology, Nephrology, and Endocrinology (A.-S.S., A.-L.T., U.P.-B., P.E.), Nordsjællands Hospital, DK-3400 Hillerød, Denmark; Faculty of Health Sciences (A.-S.S.), University of Southern Denmark, DK-5000 Odense, Denmark; and Faculty of Health Sciences (U.P.-B., P.E.), University of Copenhagen, DK-2200 Copenhagen, Denmark.
This case study shows that syndrome of inappropriate antidiuretic hormone secretion (SIADH) can cause severe osteoporosis. Bone metabolism improved significantly after the SIADH cause was treated, indicating a reversible condition.
Area of Science:
- Endocrinology
- Bone Metabolism
- Oncology
Background:
- Emerging evidence links hyponatremia with osteoporosis.
- Previously, a severe male osteoporosis case was linked to chronic SIADH.
- This follow-up reinforces a potential causal relationship.
Observation:
- A 38-year-old man presented with severe osteoporosis attributed to chronic SIADH.
- An esthesioneuroblastoma secreting ADH was identified as the cause.
- Tumor removal led to normalization of ADH and sodium levels.
Findings:
- Bone mineral density significantly improved in lumbar vertebrae 7 months post-surgery.
- This demonstrates a reversible impact of SIADH on bone metabolism.
- Esthesioneuroblastoma secreting ADH can cause severe secondary osteoporosis.
Implications:
- This case supports a causal link between SIADH, chronic hyponatremia, and impaired bone metabolism.
- It highlights the potential for osteoporosis treatment by addressing the underlying SIADH cause.
- The findings suggest that SIADH-induced osteoporosis may be partially reversible.
