Antibiotic-impregnated cement embedding technique for spinal instrumentation infections

Area of Science:

• Orthopedic Surgery
• Infectious Disease Management
• Biomaterials Science

Background:

• Spinal instrumentation infections are challenging due to implant-associated biofilms.
• Existing treatments for infected spinal implants are often invasive, costly, and time-consuming.
• Patient quality of life is frequently compromised by current management strategies.

Observation:

• A novel technique involving meticulous débridement and embedding of metallic implants in antibiotic-infused polymethylmethacrylate (PMMA) was applied.
• This procedure was performed on 13 consecutive patients with post-spinal instrumentation infections.
• Postoperative patient activity was not restricted, and implants were retained unless revision surgery was necessary.

Findings:

• Nine out of 13 patients achieved cure following débridement and PMMA embedding with systemic antibiotics.
• The treatment was effective even in cases involving methicillin-resistant Staphylococcus aureus (MRSA).
• No complications were reported during the study period.

Implications:

• Antibiotic-impregnated PMMA embedding offers an effective and straightforward approach for treating spinal instrumentation infections.
• This technique demonstrates efficacy against challenging pathogens like MRSA.
• The method holds potential for improving patient outcomes and reducing treatment burdens in spinal infection management.