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A role for class I MHC antigens in responses of activated B lymphocytes
1Department of Biology, University of California, San Diego, La Jolla 92093.
Expression of the H-2 D protein was increased over 10-fold in B cells activated by IL-4 IL-5, IFN-gamma or LPS. Differences in the regulation of H-2 D expression and in growth rates were detected during lymphokine-triggered responses of subpopulations of splenic B cells. The enhancement of H-2 D expression on activated B cells was regulated at the transcriptional level and required synthesis of an intermediate cellular protein(s). B cell growth and differentiation were inhibited by antibodies to the H-2 D Ag suggesting a signaling function for the class I molecules on activated B lymphocytes. In T cells, a similar elevation of H-2 D expression occurred after stimulation with IL-5 or Con A.
Expression of the H-2 D protein was increased over 10-fold in B cells activated by IL-4 IL-5, IFN-gamma or LPS. Differences in the regulation of H-2 D expression and in growth rates were detected during lymphokine-triggered responses of subpopulations of splenic B cells. The enhancement of H-2 D expression on activated B cells was regulated at the transcriptional level and required synthesis of an intermediate cellular protein(s). B cell growth and differentiation were inhibited by antibodies to the H-2 D Ag suggesting a signaling function for the class I molecules on activated B lymphocytes. In T cells, a similar elevation of H-2 D expression occurred after stimulation with IL-5 or Con A.