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Ovulation induction with clomiphene citrate for infertile couple
1Department of Surgery Obstetrics and Gynecology, University of Catania, Catania, Italy - federicagrasso88@gmail.com.
Minerva Ginecologica
|June 28, 2014
Summary
Clomiphene citrate (CC) combined with intrauterine insemination (IUI) significantly improves pregnancy rates for couples with unexplained infertility. This approach enhances fecundity without requiring more invasive fertility treatments.
Area of Science:
- Reproductive Medicine
- Infertility Treatment
Background:
- Unexplained infertility affects 30% of couples struggling to conceive.
- Management strategies for unexplained infertility often involve ovulation induction and intrauterine insemination to improve pregnancy rates.
Purpose of the Study:
- To evaluate the success rate of homologous intrauterine insemination (IUI) when combined with clomiphene citrate (CC) stimulation for unexplained infertility.
Main Methods:
- A total of 77 couples were assessed, with 68 eligible for the study.
- Couples were divided into two groups: 34 received CC for ovulation induction, and 34 received a placebo (multivitamin).
- All participants underwent homologous intrauterine insemination.
Main Results:
- The CC group (Group A) achieved 15 pregnancies (44.1%) with 3 abortions (8.8%).
- The placebo group (Group B) resulted in 4 pregnancies (11.7%) with 1 abortion (2.9%).
- CC stimulation significantly increased pregnancy rates compared to placebo.
Conclusions:
- Ovulation induction using CC alongside IUI enhances fecundity in patients with unexplained infertility.
- This combined approach offers an effective, less invasive option for improving fertility outcomes.
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