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Updated: Apr 27, 2026

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface
Published on: July 10, 2014
No trial evidence for restorative interventions in children and adolescents with amelogenesis imperfecta
1New York University, College of Dentistry, New York, USA.
Data Sources:
The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, and CINAHL databases were searched. Abstracts of the Conference Proceedings of the International Association for Dental Research and reference lists of identified articles were also scanned for relevant papers.
Study Selection:
Randomised trials where children and adolescents with AI who required restoration of teeth were allocated to different restoration techniques would have been selected.
Data Extraction And Synthesis:
Standard Cochrane review protocols would have been followed.
Results:
No studies met the inclusion criteria.
Conclusions:
We found no randomised controlled trials of restorative treatments for children and adolescents with AI, and therefore there is no evidence as to which is the best restoration. Well defined randomised controlled trials which recruit children and adolescents and focus on the type and severity of the disorder should be undertaken to determine the best intervention for restoring teeth affected by AI.

