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Updated: Apr 27, 2026
Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
Published on: May 26, 2023
Tranexamic acid reduces intraoperative blood loss in orthognathic surgery
Camelia Espahbod1, Analia Veitz-Keenan1
1NYU College of Dentistry, New York, USA.
Data Sources:
Medline, Embase and the reference lists of identified articles were also scanned for relevant papers.
Study Selection:
Only randomised controlled trials in English were considered.
Data Extraction And Synthesis:
Two reviewers extracted data independently and study quality was assessed using the Jadad score. Meta-analysis was conducted.
Results:
Four RCTs with a total of 183 patients were included. Intraoperative blood loss in the tranexamic acid group was statistically reduced (weighted mean difference [WMD] = -93.56, 95% CI = -132.59-54.52, P < .00001). No statistical difference was seen in the postoperative levels of haemoglobin and haematocrit (WMD = 0.50, 95% CIs = -0.43-1.43, P = .29 and WMD = 0.18, 95% CIs = -1.64-1.99, P = .85, respectively).
Conclusions:
This meta-analysis confirms that tranexamic acid can effectively reduce intraoperative blood loss in orthognathic surgery, especially by intravenous administration. But tranexamic acid cannot affect postoperative levels of haemoglobin and haematocrit.
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