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Updated: Apr 27, 2026

The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
Quantitative correlation of the in vitro biological effect with parameters of molecular complexation in
Anatoly S Buchelnikov1, Maxim P Evstigneev2
1Department of Biology and Chemistry, Belgorod State University, Belgorod 308015, Russia.
Abstract:
According to the theory of interceptor-protector action a quantitative link between the physico-chemical parameters of molecular complexation and in vitro biological effect in aromatic drug-interceptor systems must exist. In the present communication such link between relative change in mutagenicity of IQ-type aromatic mutagens on addition of aromatic interceptor molecules with equilibrium hetero-association constants of mutagen-interceptor complexation has been found using the published in vitro data in bacteria cell systems.
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