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The value of the Charlson Co-morbidity Index in aneurysmal subarachnoid haemorrhage

Hieronymus D Boogaarts1, Mariana P Duarte Conde, Edith Janssen

  • 1Department of Neurosurgery, Radboudumc, Geert Grooteplein Zuid 10, 6500 HB, Nijmegen, The Netherlands, Jeroen.Boogaarts@Radboudumc.nl.

Acta Neurochirurgica
|June 29, 2014
PubMed

Insights

The Charlson Comorbidity Index (CCI) does not predict outcomes for patients with aneurysmal subarachnoid hemorrhage (aSAH). This study found no added value of the CCI in case-mix correction for aSAH patient outcomes.

Area of Science:

  • Neurology
  • Neurosurgery
  • Public Health

Background:

  • Stroke prediction models often include comorbidities.
  • The utility of the Charlson Comorbidity Index (CCI) in predicting outcomes for subarachnoid hemorrhage (SAH) patients remains unclear.
  • This study investigates the association between the CCI and outcomes in patients with ruptured intracranial aneurysms.

Purpose of the Study:

  • To evaluate the association between the Charlson Comorbidity Index (CCI) and patient outcomes following aneurysmal subarachnoid hemorrhage (aSAH).
  • To determine if the CCI provides added value in predicting outcomes for aSAH patients.

Main Methods:

  • Retrospective analysis of consecutive aneurysmal subarachnoid hemorrhage (aSAH) patients treated at Radboudumc.
  • Data collected included World Federation of Neurological Surgeons (WFNS) grade, age, treatment modality, and Charlson Comorbidity Index (CCI).
  • Outcomes were assessed using the modified Rankin Scale (mRS), dichotomized as favorable (0-2) or unfavorable (3-6), with binary logistic regression analysis.

Main Results:

  • The study analyzed 371 patients with aSAH who had comorbidity data available.
  • Comorbidity, assessed by CCI, was present in 31.5% of patients.
  • Binary logistic regression analysis showed no statistically significant added value of the CCI in predicting patient outcomes (p = 0.91).

Conclusions:

  • The Charlson Comorbidity Index (CCI) is not associated with patient outcomes at 6 months post-aneurysmal subarachnoid hemorrhage (aSAH), as measured by the modified Rankin Scale (mRS).
  • The CCI does not offer additional value for case-mix correction in the context of aSAH patient outcomes.
Abstract

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