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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

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Fucoidans: pro- or antiangiogenic agents?

Nadezhda E Ustyuzhanina¹, Maria I Bilan², Natalia A Ushakova³

¹Laboratory of Glycoconjugate Chemistry.

|June 29, 2014

Summary

Fucoidans, sulfated polysaccharides from brown algae, exhibit diverse biological activities. Their structural variations, particularly sulfation and molecular weight, significantly impact anti- and pro-angiogenic properties.

Keywords:

FGF VEGF angiogenesis fucoidan structure

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Area of Science:

Marine biotechnology
Carbohydrate chemistry
Molecular pharmacology

Background:

Fucoidans are sulfated polysaccharides found in brown algae, known for diverse biological activities.
Their structural heterogeneity influences biological functions, particularly angiogenesis.

Purpose of the Study:

To review recent findings on the structural variability of fucoidans.
To summarize their anti- and pro-angiogenic properties.

Main Methods:

Literature review of recent publications on fucoidan structure and function.
Analysis of structure-activity relationships concerning angiogenesis.

Main Results:

Fucoidans show considerable structural differences in backbone, branches, monosaccharide composition, and sulfation.
The degree of sulfation and molecular weight critically influence fucoidan's biological effects on angiogenesis.
High-molecular-weight fucoidans display anti-angiogenic activity, while low-molecular-weight fractions promote angiogenesis.

Conclusions:

Fucoidan's biological activity, especially in angiogenesis, is strongly linked to its structural characteristics.
Molecular weight and sulfation are key determinants of fucoidan's pro- or anti-angiogenic effects.
Further research is needed to elucidate the impact of other structural details on fucoidan's role in angiogenesis.