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Unprecedent aminophysalin from Physalis angulata.

Rui-Zhi Men1, Ning Li1, Wan-Jing Ding2

  • 1Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, China.

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|June 29, 2014
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Summary
This summary is machine-generated.

Researchers discovered novel compounds from Physalis angulata, including aminophysalin A. Several physalins demonstrated quinone reductase induction activity, with Physalin H showing significant potential.

Keywords:
AminophysalinPhysalinPhysalis angulata LinnQR induction activity

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Physalis angulata Linn. is a plant species with potential medicinal properties.
  • Physalins are a class of natural products isolated from Physalis species.
  • Understanding the chemical constituents and biological activities of P. angulata is of scientific interest.

Purpose of the Study:

  • To isolate and characterize new and known physalins from the ethanol extract of Physalis angulata.
  • To evaluate the quinone reductase induction activities of the isolated compounds.

Main Methods:

  • Extraction and isolation of compounds using 95% ethanol.
  • Structure elucidation using Mass Spectrometry (MS), Infrared (IR) spectroscopy, Nuclear Magnetic Resonance (NMR) spectroscopy, and X-ray crystallography.
  • In vitro evaluation of quinone reductase induction activity in hepa 1c1c7 cells.

Main Results:

  • One new skeletal physalin, aminophysalin A, and one new naturally occurring 5β-hydroxy-6a-chloro-5,6-dihydrophysalin B were identified.
  • Five known physalins were also isolated and characterized.
  • Physalin H exhibited strong quinone reductase induction activity (IR value of 3.74±0.02).
  • Compounds 1, 2, 3, and 5 showed weak quinone reductase induction activity.

Conclusions:

  • The study successfully identified novel and known physalins from Physalis angulata.
  • Aminophysalin A possesses a unique structural feature with a nitrogen atom.
  • Physalin H demonstrates significant potential as a quinone reductase inducer, warranting further investigation.