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Overview of neurodevelopment and pain research, possible treatment targets

Suellen M Walker1

  • 1Portex Unit: Pain Research and Department of Anaesthesia and Pain Medicine, UCL Institute of Child Health and Great Ormond St Hospital for Children NHS Foundation Trust, 30 Guilford St, London WC1N 1EH, UK.

Best Practice & Research. Clinical Rheumatology
|June 30, 2014
PubMed

Insights

Pediatric rheumatological pain requires comprehensive assessment beyond severity, considering functional and psychosocial impacts. New methods like genotyping and neuroimaging may improve understanding and management of chronic musculoskeletal pain in children.

Area of Science:

  • Pediatric rheumatology
  • Musculoskeletal pain mechanisms
  • Pain assessment and management

Background:

  • Pain is a frequent and persistent symptom in children with rheumatological conditions.
  • In juvenile idiopathic arthritis, pain is not always correlated with disease severity.
  • Non-inflammatory musculoskeletal pain is common in children, yet management guidance is limited.

Purpose of the Study:

  • To emphasize the need for comprehensive pain assessment in pediatric rheumatology.
  • To explore advanced methods for characterizing and managing chronic musculoskeletal pain in children.
  • To highlight the importance of an integrated management approach for improved outcomes.

Main Methods:

  • Pain assessment should include characteristics, functional impact, psychosocial effects, and family interactions.
  • Evaluation of adult joint pain mechanisms offers potential treatment targets.
  • Investigating genotyping, sensory evaluation, and neuroimaging for characterizing pediatric pain.

Main Results:

  • Current pain assessment often overlooks crucial aspects beyond pain severity.
  • Limited evidence exists for managing non-inflammatory musculoskeletal pain in pediatric populations.
  • Potential exists for advanced techniques to better define and monitor chronic pain.

Conclusions:

  • A holistic pain assessment is crucial for children with rheumatological diseases.
  • Further research is needed on pain mechanisms during postnatal development.
  • Integrated management strategies utilizing advanced characterization methods can improve pain and disability outcomes.

Keywords:
ArthritisChildrenChronic painDevelopmentMusculoskeletal painNociceptionPain

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