Postnatal risk environments, epigenetics, and psychosis: putting the pieces together

Postnatal environmental factors, such as early life adversity, cannabis use, and social stressors are associated with increased risk for psychotic disorders. Understanding mechanisms that underlie increased psychosis risk is of great importance for the development of novel preventive approaches and early interventions. In a timely review article, Pishva et al. discuss available evidence suggesting that postnatal environmental risk factors contribute to psychotic disorders via epigenetic mechanisms. While the evidence supporting this hypothesis is limited and primarily based on the epigenetic profiling of psychotic patients and animal models, further investigation in this area is warranted and may bring exciting results.