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Updated: Apr 27, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
Published on: October 16, 2019
Around LTD hypothesis in motor learning
1Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan, thirano@neurosci.biophys.kyoto-u.ac.jp.
Abstract:
Long-term depression (LTD) at parallel fiber-Purkinje neuron synapses has been regarded as a primary cellular mechanism for motor learning. However, this hypothesis has been challenged. Demonstration of normal motor learning under LTD-suppressed conditions suggested that motor learning can occur without LTD. Synaptic plasticity mechanisms other than LTD have been found at various synapses in the cerebellum. Animals may achieve motor learning using several types of synaptic plasticity in the cerebellum including LTD.
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