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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

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A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
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Multiple Allele Traits01:49

Multiple Allele Traits

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The Concept of Multiple Allelism
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Contribution of endothelial cell and macrophage activation in the alterations induced by the venom of Micrurus tener tener in C57BL/6 mice.

Molecular immunology·2019
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Mutacytin-1, a New C-Type Lectin-Like Protein from the Venezuelan Cuaima (<i>Lachesis muta muta</i> Linnaeus, 1766) (Serpentes: Viperidae) Snake Venom Inducing Cardiotoxicity in Developing Zebrafish (<i>Danio rerio</i>) Embryos.

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Biochemical and biological characterisation of lancehead (<i>Bothrops venezuelensis</i> Sandner 1952) snake venom from the Venezuelan Central Coastal range.

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Overwiew of the Coagulation System and laboratory tests for its study.

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Pro-inflammatory response and hemostatic disorder induced by venom of the coral snake Micrurus tener tener IN C57BL/6 mice.

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Related Experiment Video

Updated: Apr 27, 2026

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

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[Hemostasis alterations in sickle cell syndrome].

Diego Higuera, Martha Bravo, Belsy Guerrero

    Investigacion Clinica
    |July 1, 2014
    PubMed
    Summary

    Sickle cell syndrome (SCS) involves blood disorders leading to a hypercoagulable state. Early evaluation of hemostasis components is crucial for preventing thrombotic complications in SCS patients.

    Area of Science:

    • Hematology
    • Vascular Biology
    • Thrombosis Research

    Background:

    • Sickle cell syndrome (SCS) is a group of inherited hemolytic anemias characterized by hemoglobin S.
    • SCS patients face increased risks of stroke, pulmonary hypertension, and other organ damage due to a hypercoagulable state.

    Purpose of the Study:

    • To compile and review hemostasis disorders and thrombotic manifestations in sickle cell syndrome.
    • To highlight the link between hemostasis alterations and thrombotic complications in SCS.

    Main Methods:

    • Review of existing literature on hemostasis disorders in sickle cell syndrome.
    • Analysis of coagulation, fibrinolytic, and platelet system alterations.

    Main Results:

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  • SCS patients exhibit increased coagulation activation markers and tissue factor expression.
  • Depletion of natural anticoagulants and abnormal fibrinolytic activity are observed.
  • Platelet abnormalities, including increased adhesion and aggregation, contribute to hypercoagulability.

    • Conclusions:

    • The hemostatic system's alterations in SCS create a hypercoagulable state, leading to thrombotic complications.
    • Recommends incorporating hemostasis system evaluation into SCS diagnosis and monitoring to prevent thrombotic events.