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Updated: Apr 27, 2026
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
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Basal cell carcinomas in a tertiary referral centre: a systematic analysis.
J Dreier1, P F Cheng, I Bogdan Alleman
1Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
The British Journal of Dermatology
|July 1, 2014
Summary
This study analyzed complex basal cell carcinoma (BCC) cases, finding that moderate and severe BCCs have more diverse histological subtypes and aggressive features. These findings suggest potential benefits from new therapeutic options for patients with complicated BCC.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Basal cell carcinoma (BCC) is the most common skin cancer, with rising incidence.
- While often curable, BCC can exhibit aggressive behavior and pose treatment challenges.
Purpose of the Study:
- To investigate basal cell carcinoma (BCC) subtypes, treatments, and clinical progression.
- To gather data on complex BCC cases for improved understanding and management.
Main Methods:
- Retrospective analysis of 2938 BCC cases from January 2007 to December 2011 at a single tertiary referral center.
- Data sourced from a dermatopathology database and electronic patient records.
- Classification of cases into simple, moderate, and severe based on severity estimations.
Main Results:
- Moderate (6.6%) and severe (0.6%) BCC cases showed significantly higher rates of unique histological diagnoses.
- Aggressive subtypes like basosquamous carcinoma and sclerosing BCC were more strongly associated with moderate and severe cases.
- 82.6% of patients with basosquamous carcinoma had a prior BCC history.
Conclusions:
- This study provides the first analysis of complicated BCC frequency in a tertiary center.
- Moderate and severe BCC cases exhibit greater histological diversity and association with aggressive subtypes.
- Patients with complex BCC may benefit from novel therapeutic strategies.
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