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Stimulation of arachidonic acid metabolism by CCl4 in isolated rat hepatocytes
M Marinovich1, L M Flaminio, M Papagni
1Institute of Pharmacological Sciences, Univ. of Milan, Italy.
Prostaglandins
|January 1, 1989
Abstract:
Arachidonic acid metabolism was evaluated in isolated rat hepatocytes after CCl4 exposure. CCl4 induced dose-dependently the synthesis and release of prostacyclin (PGI2) and thromboxane (TXB2). Treatment with prostaglandin E2 (PGE2) 30 min after exposure to CCl4, significantly reduced the cell damage as well as the release of TXB2 from the cells.