Schisandrin A and B affect subventricular zone neurogenesis in mouse
Yi-Xue Sun1, Yan-Long Cong1, Yang Liu1
1Jilin Provincial Key Laboratory of Animal Embryo Engineering, The Center for Animal Embryo Engineering of Jilin Province, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
European Journal of Pharmacology
|July 1, 2014
Summary
Schisandrin B enhances neurogenesis by stimulating cell proliferation in the subventricular zone (SVZ) and improving olfactory bulb (OB) interneuron survival. Schisandrin A, however, negatively regulates neurogenesis in the adult SVZ-RMS-OB system.
Area of Science:
- Neuroscience
- Pharmacology
- Traditional Chinese Medicine
Background:
- Schisandra chinensis is traditionally used for cognitive enhancement.
- Schisandrin A and B are key active compounds.
- Neuroprotective effects are known, but impact on neurogenesis is unclear.
Purpose of the Study:
- Investigate Schisandrin A and B effects on adult neurogenesis.
- Focus on the subventricular zone (SVZ), rostral migratory stream (RMS), and olfactory bulb (OB) system.
Main Methods:
- Intragastric administration of Schisandrin A and B (1, 10, 20 mg/kg/day).
- Analysis of cell proliferation (phosphohistone H3), GFAP+, doublecortin+, tyrosine hydroxylase, Calbindin+, and Calretinin+ cells.
- Focus on the 10 mg/kg/day dose.
Main Results:
- Schisandrin B increased SVZ proliferation and GFAP+ cells.
- Schisandrin A increased neuroblasts in the RMS.
- Schisandrin A decreased OB tyrosine hydroxylase and Calbindin+ cells; Schisandrin B increased OB Calbindin+ and Calretinin+ cells.
Conclusions:
- Schisandrin B promotes neurogenesis via SVZ proliferation and enhances OB interneuron survival.
- Schisandrin A promotes RMS neuroblast formation but impairs OB interneuron survival.
- Schisandrin B shows neuroprotective potential by enhancing neurogenesis; Schisandrin A negatively regulates it.
