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Evaluation of tularaemia courses: a multicentre study from Turkey.
H Erdem1, D Ozturk-Engin, M Yesilyurt
1Department of Infectious Diseases and Clinical Microbiology, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
Summary
Tularaemia, a prolonged illness, often presents with oropharyngeal or glandular symptoms and enlarged lymph nodes. Despite antibiotic treatment, nearly half of patients experienced treatment failure, indicating a need for optimized strategies.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Tularaemia is a zoonotic disease caused by Francisella tularensis.
- Accurate diagnosis and effective treatment are crucial for patient outcomes.
Purpose of the Study:
- To describe the clinical features, diagnostic findings, and treatment outcomes of tularaemia.
- To identify factors contributing to treatment failure in tularaemia patients.
Main Methods:
- Retrospective analysis of 1034 tularaemia patients from 41 medical centres.
- Review of preliminary diagnoses, clinical presentations, lymph node characteristics, imaging, histology, and treatment regimens.
- Analysis of treatment outcomes, including failure rates and reasons for failure.
Main Results:
- Oropharyngeal (85.3%), glandular (13.1%), and oculoglandular (10.1%) forms were most common.
- Enlarged lymph nodes (95.5%) were frequent, with cervical and submandibular chains most affected.
- Treatment failure occurred in 48% of patients, often due to lymph node suppuration or persistent symptoms.
Conclusions:
- Tularaemia is a protracted but treatable disease.
- Current treatment strategies require optimization to improve outcomes and reduce failure rates.
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