Related Experiment Video For Biologic attributes
Updated: Apr 27, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
The unique pathology of nonpolypoid colorectal neoplasia in IBD
Carlos A Rubio1, Premysl Slezak2
1Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm 17176, Sweden.
Abstract:
Patients with inflammatory bowel disease may develop dysplasia in the cryptal epithelium, polypoid neoplasias, and nonpolypoid (flat) adenomas, lesions at risk to proceed to colorectal carcinoma. The onset of invasion in nonpolypoid adenomas may occur without changes in the shape or the size of the lesion. In experimental animals, some colonotropic carcinogens induce polypoid and nonpolypoid neoplasias and others induce polypoid neoplasias exclusively. Some of the biologic attributes of nonpolypoid adenomas in humans can be demonstrated in laboratory animals.
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