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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Related Experiment Video

Updated: Apr 27, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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Biomarkers for post thrombotic syndrome: a case-control study.

A C Bouman1, Y W Cheung2, H M Spronk3

  • 1Laboratory for Thrombosis and Hemostasis, Maastricht University Medical Centre, Universiteitssingel 50, Maastricht, the Netherlands; Department of Internal Medicine, Maastricht University Medical Centre, P.Debyelaan 25, Maastricht, the Netherlands.

Thrombosis Research
|July 1, 2014
PubMed
Summary

Post thrombotic syndrome (PTS) involves increased coagulation and endothelial activation, but not systemic inflammation. Biomarker analysis reveals altered fibrinolytic patterns in PTS patients following deep vein thrombosis (DVT).

Keywords:
BiomarkersCase-control studyEtiologyPost thrombotic syndromeVenous thrombosis

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Area of Science:

  • Vascular Biology
  • Thrombosis Research
  • Biomarker Discovery

Background:

  • Limited understanding of post thrombotic syndrome (PTS) etiology despite proposed mechanisms.
  • Need to investigate pathogenic mechanisms of PTS using comprehensive biomarker analysis.

Purpose of the Study:

  • To explore the role of different pathogenic mechanisms in PTS development.
  • To measure an elaborate panel of biomarkers in patients with and without PTS.

Main Methods:

  • Comparative study of deep vein thrombosis (DVT) patients with PTS (cases) and without PTS (controls).
  • Inclusion of healthy individuals (HI) as a reference population.
  • Measurement of a predefined panel of venous blood biomarkers.

Main Results:

  • Elevated thrombin/antithrombin complex and decreased APC-ratio in PTS cases.
  • Significant trends observed in D-dimer, pro-thrombotic factors (proTAFI), and soluble VCAM (sVCAM).
  • Increased endothelial activation markers (thrombomodulin, tPA, vWF) in patients versus HI; no systemic inflammation.

Conclusions:

  • PTS is characterized by increased coagulation activity and altered fibrinolysis.
  • Evidence of endothelial activation in PTS patients.
  • No systemic inflammation detected in PTS patients at 63 months post-DVT.