Related Experiment Video

Updated: Apr 27, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

9.6K

Serum leukotrienes, circulating neutrophils, and high sensitivity C-reactive protein in Chinese children with

Yuelin Shen1, Qiang Qin2, Zhifei Xu3

  • 1Department No. 2 of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, People's Republic of China.

International Immunopharmacology
|July 1, 2014
PubMed

Insights

Children with sleep-disordered breathing (SDB) show increased systemic inflammation, indicated by elevated leukotrienes (LTs), neutrophil counts, and hsCRP. These inflammatory markers correlate with SDB severity and are linked to LT production.

Area of Science:

  • Pediatric Pulmonology
  • Immunology
  • Sleep Medicine

Background:

  • Leukotriene (LT) levels increase with disease severity in sleep-disordered breathing (SDB) patients' breath and urine.
  • Limited research exists on circulating LTs' role in SDB systemic inflammation.
  • The relationship between LT production, leukocyte count, and hsCRP in SDB is debated.

Purpose of the Study:

  • To investigate the association between serum leukotrienes (LTs) and systemic inflammation markers in children with SDB.
  • To determine if LT levels, neutrophil counts, and hsCRP correlate with SDB severity.

Main Methods:

  • Prospective observational study involving questionnaires, physical exams, and polysomnography.
  • Serum leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) measured via enzyme-linked immunosorbent assays.
  • Neutrophil (Neu) count and high-sensitivity C-reactive protein (hsCRP) levels analyzed.

Main Results:

  • 166 children with SDB and 45 controls were studied.
  • SDB children exhibited higher serum LTB4, cysLTs, Neu count, and hsCRP compared to controls.
  • All inflammatory markers showed disease severity-dependent increases and correlated with LT production.

Conclusions:

  • Children with SDB exhibit an activated systemic inflammatory response, evidenced by elevated serum LTs, neutrophil counts, and hsCRP.
  • The degree of inflammation is dependent on SDB severity.
  • Serum LT levels are significantly associated with circulating neutrophil counts and hsCRP values in SDB.
Abstract

Keywords:
Cysteinyl leukotrienesHigh sensitivity C-reactive proteinLeukotriene B(4)NeutrophilSleep-disordered breathingSystemic inflammation

More Related Videos

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

9.1K
Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

2.2K

Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
2.2K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
751
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
88
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
38