Related Experiment Video

Updated: Apr 27, 2026

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.3K

Naringin suppress chondrosarcoma migration through inhibition vascular adhesion molecule-1 expression by modulating

Tzu-Wei Tan1, Ying-Erh Chou2, Wei-Hung Yang3

  • 1Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

International Immunopharmacology
|July 1, 2014
PubMed

Insights

Naringin, a citrus flavonoid, inhibits chondrosarcoma cell migration and invasion without affecting apoptosis. It reduces VCAM-1 expression by upregulating miR-126, suggesting potential as an anti-migration therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Chondrosarcoma is a primary bone cancer with high metastatic potential and poor patient prognosis.
  • Naringin, a flavonoid from citrus fruits, exhibits antioxidant, anti-inflammatory, and anti-tumor properties.
  • The effect of naringin on chondrosarcoma cell migration remains largely unexplored.

Purpose of the Study:

  • To investigate the effect of naringin on chondrosarcoma cell migration and invasion.
  • To elucidate the molecular mechanisms underlying naringin's action on chondrosarcoma cells.

Main Methods:

  • Human chondrosarcoma cells were treated with naringin at non-cytotoxic concentrations.
  • Cell migration and invasion assays were performed.
  • Messenger RNA (mRNA) and cell surface expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) were analyzed.
  • MicroRNA-126 (miR-126) expression levels were assessed.
  • The effect of a miR-126 inhibitor on cell motility and VCAM-1 expression was evaluated.

Main Results:

  • Naringin did not induce apoptosis in human chondrosarcoma cells.
  • Naringin significantly suppressed chondrosarcoma cell migration and invasion.
  • Naringin reduced both mRNA transcription and cell surface expression of VCAM-1.
  • Naringin treatment led to enhanced expression of miR-126.
  • Inhibition of miR-126 reversed the effects of naringin on cell motility and VCAM-1 expression.

Conclusions:

  • Naringin inhibits migration and invasion of human chondrosarcoma cells.
  • This inhibition is mediated by the down-regulation of VCAM-1 through the upregulation of miR-126.
  • Naringin shows potential as a novel therapeutic agent against chondrosarcoma metastasis.
Keywords:
ChondrosarcomaMigrationNaringinVascular cell adhesion molecule-1miR-126

More Related Videos

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

8.4K
Preparation of Naringenin Solution for In Vivo Application08:18

Preparation of Naringenin Solution for In Vivo Application

Published on: August 10, 2021

2.9K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
20.9K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.2K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

4.9K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K