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Updated: Apr 27, 2026

A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Massive pulmonary embolism in a young boy with T-cell leukaemia. Successful thrombolytic therapy by recombinant
1Olaf Beck, MD, Children`s Hospital, Paediatric Haematology and Oncology, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany, Tel. +49/(0)61 31/17 35 20, Fax +49/(0)61 31/17 64 69,
Abstract:
Acute pulmonary embolism (PE) is a serious complication in association with malignant diseases. We describe the successful treatment of PE applying a systemic thrombolytic therapy in a 4-year-old boy with acute lymphoblastic leukaemia. The thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) 0.1 mg/kg bodyweight per hour for six hours was continued for six days without important side effects. In particular no bleeding complications were observed. Computed tomography with contrast revealed a remarkable regression of the central PE. Without further delays the chemotherapy was resumed.
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