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Related Concept Videos

Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

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Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
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Related Experiment Video

Updated: Apr 27, 2026

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
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Recurrence pattern after conservative surgery for papillary thyroid carcinoma.

Kenya Kobayashi1, Shigeo Takenouchi2, Hiroki Mitani3

  • 1Department of Otolaryngology, Head and Neck Surgery, Takeda General Hospital, Japan; Department of Otolaryngology, Head and Neck Surgery, The University of Tokyo Hospital, Tokyo, Japan.

Auris, Nasus, Larynx
|July 1, 2014
PubMed
Summary

Conservative surgery may be suitable for low-risk papillary thyroid carcinoma. Recurrence patterns differ by risk group, with contralateral lobe involvement increasing neck recurrence risk.

Keywords:
Conservative surgeryPapillary thyroid carcinomaPattern of recurrenceRisk-based treatment

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Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Thyroid Cancer Research

Background:

  • Risk-based treatment is optimal for papillary thyroid carcinoma.
  • Optimal extent of surgery (thyroidectomy, neck dissection) is debated.

Purpose of the Study:

  • To clarify recurrence patterns after conservative surgery for papillary thyroid carcinoma.
  • To identify risk factors influencing recurrence and survival.

Main Methods:

  • Retrospective review of 93 patients with papillary thyroid carcinoma.
  • Analysis of recurrence rates, patterns, risk factors, and disease-free survival (DFS) stratified by risk.

Main Results:

  • Lower recurrence in low-risk (14%) vs. high-risk (34%) groups (p<0.01).
  • Ipsilateral neck recurrence more common in low-risk; contralateral in high-risk.
  • Contralateral thyroid lobe metastasis/invasion significantly increased contralateral neck recurrence. Overall 5-year DFS was 81%.

Conclusions:

  • Conservative surgery may be a viable option for low-risk papillary thyroid carcinoma.
  • Recurrence patterns vary by risk group.
  • Contralateral thyroid lobe lesions and invasion are risk factors for contralateral neck recurrence.