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Related Concept Videos

Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

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Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
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Components of Stress01:23

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Stress analysis under multiple loading conditions is intricate, necessitating a comprehensive grasp of normal and shearing stresses. Consider a small cube at point O, subjected to stress on all six faces, visible or not. Normal stress components σx, σy, σz act perpendicularly to the x, y, and z axes. Shearing stress components τxy and τxz are exerted on faces perpendicular to these axes.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Apr 27, 2026

Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model
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Author Spotlight: Exploring Microglial Interactions with Stress-Response Circuitry Using the Limited Bedding and Nesting Model

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Neuroepigenetics of stress.

B B Griffiths1, R G Hunter1

  • 1University of Massachusetts, Boston, MA, United States.

Neuroscience
|July 1, 2014
PubMed
Summary

Stress impacts physiology and behavior, with epigenetic marks influencing individual differences in stress response. Early life stress can lead to lasting effects on cognition, behavior, and psychiatric disorder risk across generations.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Individual stress susceptibility and resilience vary significantly.
  • Genetic factors alone do not fully explain these variations.
  • The developmental programming of the hypothalamic-pituitary-adrenal (HPA) axis is a key factor.

Purpose of the Study:

  • To explore the role of epigenetic mechanisms in stress responsiveness.
  • To understand how environmental factors, particularly stress, influence gene expression.
  • To investigate the intergenerational effects of stress on epigenetic marks.

Main Methods:

  • Utilizing epigenetic approaches to bridge the gap between genes and environment.
  • Examining the bi-directional interaction between stress, the HPA axis, and brain epigenetic marks.
Keywords:
DNA methylationHPA axiscorticosteroidsdevelopmental programinghistone modificationsnon-coding RNA

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Related Experiment Videos

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  • Analyzing the acute and lasting effects of stress exposure, especially in early life.

    • Main Results:

    • Epigenetic modifications help explain individual differences in stress response.
    • Stress exposure, particularly early in life, alters epigenetic marks.
    • These epigenetic changes impact cognitive function, behavior, and psychiatric disorder risk.

    Conclusions:

    • Epigenetic mechanisms are crucial for understanding stress resilience and susceptibility.
    • Early life stress has profound and potentially transgenerational consequences mediated by epigenetics.
    • Targeting epigenetic pathways may offer novel therapeutic strategies for stress-related disorders.