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Updated: Apr 27, 2026
07:42
An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
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Candida infections and their prevention.
M Anaul Kabir1, Zulfiqar Ahmad2
1Molecular Genetics Laboratory, School of Biotechnology, National Institute of Technology Calicut, Calicut 673601, India.
ISRN Preventive Medicine
|July 1, 2014
Summary
Candida infections are rising globally, especially in immunocompromised individuals. New strategies, including drug combinations and biomedicines, are crucial for overcoming antifungal resistance and effectively treating candidiasis.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Drug Discovery
Background:
- Global increase in Candida infections, particularly among immunocompromised populations.
- Limitations of current antifungal drugs, including resistance development and side effects.
- Need for advanced diagnostic and therapeutic strategies for candidiasis.
Purpose of the Study:
- To review current strategies for preventing and treating Candida infections.
- To highlight the role of early detection and speciation in antifungal therapy.
- To explore alternative and complementary approaches to combat antifungal drug resistance.
Main Methods:
- Review of existing literature on Candida infections and antifungal treatments.
- Discussion of modern diagnostic technologies (e.g., MALDI-TOF-MS, PCR, DNA microarray).
- Exploration of therapeutic strategies including drug combinations, efflux pump inhibitors, and biomedicines.
Main Results:
- Antifungal drug resistance is a significant challenge in treating candidiasis.
- Advanced technologies enable faster and more accurate Candida strain detection.
- Combination therapies and biomedicines show promise in overcoming resistance and improving safety.
Conclusions:
- Understanding Candida biology through advanced technologies is key to developing effective treatments.
- Combination antifungal therapy and novel biomedicines offer potential solutions to drug resistance.
- Integrated approaches combining diagnostics and therapeutics are essential for managing candidiasis.
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