Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

31
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
31
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

32
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
32

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiological, Histopathological, and Surgical Outcomes of Intradural Spinal Ependymomas: A Single-Center Retrospective Series.

World neurosurgery·2026
Same author

Explainable benchmarking of U-Net variants for lung segmentation on chest radiographs.

Tuberkuloz ve toraks·2026
Same author

Serum asprosin levels as a subclinical atherosclerosis marker in patients with primary hypertension.

BMC cardiovascular disorders·2026
Same author

Prediction of Hemorrhagic Transformation and Functional Outcomes Using Arterial Spin Labeling MRI in Acute Middle Cerebral Artery Infarction.

Noro psikiyatri arsivi·2026
Same author

Noninvasive Assessment Follow-Up of Progress in MS Patients.

Noro psikiyatri arsivi·2026
Same author

Theoretical modeling of <sup>65</sup>Zn production via charged particle reactions on <sup>66</sup>Zn.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2025

Related Experiment Video

Updated: Apr 27, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

27.9K

The limbic degradation of aging brain: a quantitative analysis with diffusion tensor imaging.

Hediye Pınar Gunbey1, Karabekir Ercan2, Ayşe Serap Fındıkoglu3

  • 1Radiology Department, Ondokuz Mayıs University, Kurupelit, 55139 Samsun, Turkey.

Thescientificworldjournal
|July 1, 2014
PubMed
Summary

Aging significantly impacts white matter integrity in the limbic system, particularly the hippocampus, parahippocampus, and fornix, as revealed by diffusion tensor imaging (DTI) in healthy adults.

More Related Videos

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.2K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.2K

Related Experiment Videos

Last Updated: Apr 27, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

27.9K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.2K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.2K

Area of Science:

  • Neuroimaging
  • Gerontology
  • White Matter Integrity

Background:

  • The limbic system, crucial for emotion and memory, degrades with age.
  • Diffusion tensor imaging (DTI) assesses white matter integrity.

Purpose of the Study:

  • Investigate age-related changes in limbic system diffusivity and fiber characteristics.
  • Examine quantitative diffusivity parameters and fiber characteristics in healthy volunteers.

Main Methods:

  • 31 healthy subjects (25-70 years) underwent 1.5 TMR MRI.
  • Quantitative fiber tracking of fornix, cingulum, and parahippocampal gyrus.
  • Measured fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in key limbic structures.

Main Results:

  • Negative correlation between aging and FA in left hippocampus, bilateral parahippocampal gyrus, and fornix.
  • ADC values showed mixed correlations with age in amygdala and hippocampus.
  • Significant age-related FA changes observed in cingulum and parahippocampal gyrus per decade.

Conclusions:

  • Aging significantly affects the hippocampus, parahippocampus, and fornix, but not the cingulum.
  • Findings highlight age-related limbic system changes in a normal population.
  • Contributes to future DTI studies on aging and the limbic system.