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Author Spotlight: Developing a Unique Modular Microphysiological System to Mimic Human Barrier Tissue

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Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis.

Olivier Frey¹, Patrick M Misun¹, David A Fluri²

¹ETH Zürich, Department of Biosystems Science and Engineering, Bio Engineering Laboratory, Mattenstrasse 26, CH-4058 Basel, Switzerland.

Nature Communications

|July 1, 2014

Summary

This summary is machine-generated.

This study introduces a flexible microfluidic platform using hanging-drop technology to create interconnected multi-tissue systems. This innovation facilitates studying organ interactions for advanced

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Area of Science:

Biotechnology
Tissue Engineering
Microfluidics

Background:

Organ-to-organ interactions are crucial for understanding systemic physiology.
Current models often lack the complexity to replicate in vivo conditions accurately.
Microfluidic systems offer potential for advanced biological research.

Purpose of the Study:

To develop a versatile microfluidic platform for integrating multiple three-dimensional microtissues.
To enable the study of inter-organ communication and metabolic interactions.
To advance 'body-on-a-chip' research capabilities.

Main Methods:

Extension of hanging-drop technology for multi-cellular spheroid formation.
Creation of an open, 'hanging' microfluidic system on a substrate.
Parallelized microtissue formation and subsequent interconnection via fluidic network reconfiguration.
Precise control of liquid flow for nutrient supply and substance dosage.

Main Results:

High flexibility in microtissue arrangement and interconnection was achieved.
Simple fabrication and robust operation of the microfluidic platform.
Demonstrated capability for parallelized formation and complex multi-tissue experiments.
Enabled precise control over nutrient delivery and inter-organ communication.

Conclusions:

The developed platform offers a promising technology for 'body-on-a-chip' research.
Facilitates novel insights into organ interactions and systemic physiology.
Represents a significant advancement in creating complex, interconnected microtissue models.