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Hyper-adhesion: a unique property of desmosomes
David Garrod1, Lydia Tabernero
1Faculty of Life Sciences, University of Manchester , Manchester , UK.
Cell Communication & Adhesion
|July 1, 2014
Summary
Hyper-adhesion, a strong desmosomal adhesion, maintains tissue integrity. This review defines hyper-adhesion and explores its roles in development, healing, and skin disease.
Area of Science:
- Cell biology
- Tissue engineering
- Dermatology
Background:
- Desmosomal adhesion is crucial for tissue integrity.
- Hyper-adhesion represents a distinct, potent form of this adhesion.
- Understanding hyper-adhesion is key to various biological processes.
Purpose of the Study:
- To define hyper-adhesion.
- To review evidence supporting hyper-adhesion in vitro and in vivo.
- To discuss the implications of hyper-adhesion in development, wound healing, and skin disease.
Main Methods:
- Literature review and synthesis.
- Analysis of existing data on desmosomal adhesion.
- Speculative modeling of molecular and cellular mechanisms.
Main Results:
- Hyper-adhesion is characterized by exceptionally strong cell-cell connections.
- Evidence for hyper-adhesion exists in both cultured cells and living organisms.
- Its presence is linked to critical physiological and pathological processes.
Conclusions:
- Hyper-adhesion plays a significant role in maintaining tissue integrity.
- Further research into its molecular underpinnings is warranted.
- Potential therapeutic targets for skin diseases may emerge from studying hyper-adhesion.
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