Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

888
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
888
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.1K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

8.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.0K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

965
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
965

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and myocardial bridging: a cross-sectional study.

Cardiovascular journal of Africa·2026
Same author

Balloon-Assisted Stent Advancement Technique for Stent Delivery Failure in Complex Percutaneous Coronary Intervention.

JACC. Case reports·2026
Same author

Does Serum γKlotho Truly Provide Incremental Prognostic Value Beyond Established Risk Predictors in Multivessel Coronary Artery Disease?

Clinical cardiology·2026
Same author

Long-term diabetic nephropathy-related dialysis and mortality after acute myocardial infarction: a marker of advanced cardiovascular disease?

Heart and vessels·2026
Same author

The Relationship between Inflammation-Oxidative Stress and Lipoprotein (a) Levels in Healthy Subjects.

Acta Cardiologica Sinica·2026
Same author

PCI for Ostial Stenosis of Left Circumflex or Left Anterior Descending Artery.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2026

Related Experiment Video

Updated: Apr 27, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.8K

Lower vitamin D level is associated with poor coronary collateral circulation.

Irfan Sahin1, Ertugrul Okuyan, Baris Gungor

  • 1Department of Cardiology, Bagcilar Training and Research Hospital , Istanbul , Turkey.

Scandinavian Cardiovascular Journal : SCJ
|July 1, 2014
PubMed
Summary

Lower vitamin D levels are linked to poorer coronary collateral circulation in patients with stable coronary artery disease (CAD). This suggests vitamin D may play a role in the development of these vital blood vessels.

Keywords:
collateralcoronary artery diseaseparathyroid hormonevitamin D

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

4.9K
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

14.9K

Related Experiment Videos

Last Updated: Apr 27, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.8K
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

4.9K
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

14.9K

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D is crucial for calcium and bone homeostasis and parathyroid hormone (PTH) secretion.
  • Previous studies suggest links between low vitamin D and cardiovascular diseases.
  • The association between vitamin D and coronary collateral circulation (CCC) in stable coronary artery disease (CAD) remains unexplored.

Purpose of the Study:

  • To investigate the relationship between vitamin D levels and collateral artery development in patients with stable CAD.
  • To determine if vitamin D deficiency is associated with poor CCC in this patient population.

Main Methods:

  • A cohort of 214 patients with significant coronary artery stenosis underwent coronary angiography (CAG).
  • Coronary collateral circulation (CCC) was assessed using the Rentrop classification, categorizing patients into poor (Grade 0-1) and control (Grade 2-3) groups.
  • Serum vitamin D and PTH levels were measured on the day of CAG.

Main Results:

  • Patients with poor CCC exhibited significantly lower vitamin D levels (34 ± 25 pmol/L vs. 49 ± 33 pmol/L; p=0.01).
  • The prevalence of vitamin D deficiency (< 37 pmol/L) was higher in the poor CCC group (67% vs. 43%; p=0.01).
  • Lower vitamin D levels, female gender, and lower HDL cholesterol were independently associated with poor CCC.

Conclusions:

  • Reduced vitamin D levels are associated with impaired collateral artery development in patients with stable CAD.
  • These findings highlight a potential role for vitamin D in coronary collateralization.