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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Updated: Apr 27, 2026

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
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Polypoidal choroidal vasculopathy in white patients.

Stephen J Davis1, Andreas K Lauer, Christina J Flaxel

  • 1Casey Eye Institute, Oregon Health and Science University, Portland, Oregon.

Retina (Philadelphia, Pa.)
|July 1, 2014
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Summary

Polypoidal choroidal vasculopathy (PCV) can mimic age-related macular degeneration in white patients. Early diagnosis and photodynamic therapy significantly improve or maintain vision while reducing anti-VEGF injection frequency.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Research

Background:

  • Polypoidal choroidal vasculopathy (PCV) is a subtype of exudative age-related macular degeneration.
  • PCV diagnosis and management in white populations require further elucidation.
  • Distinguishing PCV from typical AMD is crucial for effective treatment.

Purpose of the Study:

  • To describe a cohort of white patients diagnosed with PCV in the United States.
  • To highlight diagnostic challenges and treatment outcomes for PCV in this demographic.

Main Methods:

  • Retrospective chart review of 27 white patients with PCV at a single institution.
  • Analysis of presenting symptoms, diagnostic timelines, and treatment modalities.

Main Results:

  • The average age of patients was 74.3 years, with 48% males.
  • Common misdiagnosis was exudative AMD, with a mean diagnostic delay of 17.5 months.
  • Photodynamic therapy (PDT) led to fluid reduction in 86%, with 41% experiencing vision improvement and 36% maintaining stable vision.
  • Post-PDT, anti-VEGF injection frequency decreased by 67%.

Conclusions:

  • PCV can present as recalcitrant exudative AMD in white patients, underscoring diagnostic importance.
  • Temporal or peripapillary location and presence of lipid were common findings.
  • PDT followed by anti-VEGF therapy improved or maintained vision in 77% of patients, reducing treatment burden.