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Related Experiment Video

Updated: Apr 27, 2026

Production of High-Titer Infectious Influenza Pseudotyped Particles with Envelope Glycoproteins from Highly Pathogenic H5N1 and Avian H7N9 Viruses

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Silver nanoparticles impair Peste des petits ruminants virus replication.

Nitin Khandelwal¹, Gurpreet Kaur¹, Kundan Kumar Chaubey²

¹School of Biotechnology, Rajiv Gandhi Technical University, Airport Road, Bhopal, Madhya Pradesh 462036, India.

|July 1, 2014

Summary

Silver nanoparticles (SNPs) effectively inhibited Peste des petits ruminants virus (PPRV) replication in vitro. These SNPs block virus entry into cells, offering a novel antiviral strategy against Morbillivirus infections.

Keywords:

Antiviral activity PPR virus Peste des petits ruminants SNPs Silver nanoparticles

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Published on: November 1, 2011

Area of Science:

Nanotechnology
Virology
Materials Science

Background:

Peste des petits ruminants virus (PPRV) is a significant pathogen within the Morbillivirus genus.
Developing effective antiviral agents against PPRV is crucial for animal health.

Purpose of the Study:

To evaluate the antiviral efficacy of biologically synthesized silver nanoparticles (SNPs) against PPRV.
To elucidate the mechanism of SNP-mediated inhibition of PPRV replication.

Main Methods:

Biological synthesis of SNPs using Argemone maxicana leaf extract.
Characterization of SNPs via UV-vis spectroscopy, XRD, and TEM.
In vitro antiviral assays, including time-course and virus entry inhibition studies.

Main Results:

SNPs were synthesized with sizes ranging from 5-30 nm and confirmed silver structure.
Non-cytotoxic concentrations of SNPs significantly inhibited PPRV replication in Vero cells.
SNPs were found to block viral entry into target cells without direct virucidal effect.

Conclusions:

Biologically synthesized SNPs demonstrate potent in vitro antiviral activity against PPRV.
SNPs interfere with the Morbillivirus replication cycle by inhibiting viral entry.
This study provides the first evidence of SNPs inhibiting Morbillivirus replication.