Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

119
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
119
Gene Therapy00:59

Gene Therapy

22.1K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
22.1K
Gene Therapy00:59

Gene Therapy

4.4K
4.4K
What is Genetic Engineering?00:49

What is Genetic Engineering?

70.4K
Overview
70.4K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

324
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
324

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Serum Angiopoietin-Like Protein 7 With Ferroptosis-Related Proteins in Patients With Metabolic Dysfunction-Associated Fatty Liver Disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Structural and Pharmacological Basis for the State-Dependent Activation of the Autoinhibited <i>P. aeruginosa</i> ClpP2 Protease.

ACS chemical biology·2026
Same author

Synergy between varied Pd sites on CeO<sub>2</sub> for enhanced low-temperature passive NO<sub>x</sub> adsorption.

Journal of colloid and interface science·2026
Same author

Gpat3 Knockout Attenuates Adipose Loss and Steatohepatitis in Agpat2-Deficient Mice.

The American journal of pathology·2026
Same author

Correction: Evaluating the coupling coordination between Healthy Beijing initiative and economic development.

Frontiers in public health·2026
Same author

Seipin expression in hepatocytes impairs the assembly of VLDLs and exacerbates steatohepatitis.

Journal of lipid research·2026

Related Experiment Video

Updated: Apr 27, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

1.5K

Gene therapy for obesity: progress and prospects.

Mingming Gao1, Dexi Liu

  • 1Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green, Pharmacy South, Athens, GA 30602, USA.

Discovery Medicine
|July 1, 2014
PubMed
Summary

Gene therapy offers a promising approach to combat obesity by targeting specific genes to promote fat reduction and energy expenditure. This review explores recent advancements, challenges, and future directions for gene therapy in treating obesity and related diseases.

More Related Videos

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

11.7K
An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

1.8K

Related Experiment Videos

Last Updated: Apr 27, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

1.5K
Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

11.7K
An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

1.8K

Area of Science:

  • Molecular biology
  • Genetics
  • Metabolic diseases

Background:

  • Obesity is a global epidemic with complex molecular underpinnings.
  • Gene therapy is emerging as a key strategy to address obesity and associated conditions.

Purpose of the Study:

  • To review recent progress in identifying obesity-related genes.
  • To summarize gene therapy applications for obesity treatment and prevention.
  • To discuss the advantages and limitations of current gene therapy strategies.

Main Methods:

  • Review of scientific literature on gene therapy for obesity.
  • Identification of genes implicated in obesity pathogenesis.
  • Analysis of gene delivery and expression techniques.

Main Results:

  • Gene therapy aims to modulate gene products to enhance lipolysis and energy expenditure.
  • Successful gene delivery and expression are crucial for therapeutic efficacy.
  • Restoring energy homeostasis is the primary objective.

Conclusions:

  • Gene therapy holds significant potential for treating obesity and related diseases.
  • Further research is needed to develop novel and effective gene therapy strategies.
  • Overcoming challenges in delivery and expression will be key to clinical success.