Related Experiment Video
Updated: Apr 27, 2026
Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
Impact of endobronchial coiling for lung volume reduction on pulmonary volume and attenuation: preinterventional and
Ulrich Grosse1, Jörg Hetzel, Lutz Gündel
1From the *Diagnostic and Interventional Radiology and †Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen; and ‡Computed Tomography, Siemens Medical Solutions, Forchheim, Germany.
Objective:
The aim of this study was to objectify changes in volume and density of treated and untreated pulmonary lobes following endobronchial coiling for lung volume reduction by comparison with clinical (6-m walk test) and pulmonary function tests.
Methods:
Twenty-two lobes in 17 patients (8 men, 9 women) were treated by endobronchial coiling and underwent preinterventional and postinterventional computed tomography examinations (inspiratory and expiratory phase) as well as pulmonary function test measurements.
Results:
Responders (n = 14) presented a significant increase (70 ± 11 m) in the walking distance (6-m walk test) and FEV1 (forced expiratory volume in 1 second) values (61 ± 21 mL). Only in responders inspiratory volume (VolIn) of the target lobe significantly decreased (10.0% ± 16.4%; P = 0.0245), and VolIn of the nontreated ipsilateral lobe significantly increased (5.5% ± 9.1%; P = 0.0209).
Conclusions:
Our results objectify volume reduction of the treated lobe coupled by a significant volume expansion of the ipsilateral lobe as a sole correlate for clinical improvement in responders.
