Comparison of cystatin-C and pentraxin-3 in coronary atherosclerosis
Yusuf C Doganer1, Umit Aydogan, Mustafa Aparci
1aDepartment of Family Medicine, Mayo Clinic, Rochester, Minnesota, USA bDepartment of Family Medicine cDepartment of Cardiology dDepartment of Biochemistry, Gulhane Military Medical Faculty eDepartment of Cardiology, Etimesgut Military Hospital, Ankara fBalmumcu Family Health Center, Gumussuyu Military Hospital, Istanbul, Turkey.
Insights
Cystatin-C (Cys-C) and pentraxin-3 (PTX-3) levels inversely correlate with coronary artery disease (CAD) presence and severity. These inflammation markers may help detect and assess CAD when used together.
Area of Science:
- Cardiology
- Biomarkers
- Inflammation research
Background:
- Inflammation is a key driver of atherosclerosis.
- Cystatin-C (Cys-C) and pentraxin-3 (PTX-3) are inflammatory markers.
- Their role in coronary artery disease (CAD) requires further investigation.
Purpose of the Study:
- To evaluate the relationship between Cys-C and PTX-3 levels and the presence and severity of CAD.
- To determine if these markers can aid in CAD detection and assessment.
Main Methods:
- Eighty-two stable patients undergoing coronary angiography were studied.
- Patients were categorized into significant CAD (>50% stenosis), nonsignificant CAD (<50% stenosis), and healthy groups.
- Exclusion criteria included diabetes, heart failure, and kidney disease.
Main Results:
- Patients without CAD had higher Cys-C levels (1338.96±396.71 ng/ml) compared to those with CAD (853.69±406.72 ng/ml).
- PTX-3 levels were lower in patients without CAD (110.40±48.10 pg/ml) compared to those with CAD (149.46±49.44 pg/ml).
- Both Cys-C and PTX-3 showed significant inverse correlations with CAD severity across the study groups.
Conclusions:
- Cys-C and PTX-3 levels exhibited inverse variations in relation to CAD.
- Combined use of Cys-C and PTX-3 may assist in detecting the presence and severity of CAD.
- Further validation in larger cohorts is recommended to establish definitive values.
Objective:
Inflammation is one of the numerous factors that promote atherosclerosis. Cystatin-C (Cys-C) and pentraxin-3 (PTX-3) predominantly play roles in inflammation. Thus, we evaluated whether these markers were related to the presence and severity of coronary artery disease (CAD).
Methods:
Eighty-two stable patients who had undergone coronary angiography were enrolled in the study. Patients were diagnosed with significant (>50% stenosis) and nonsignificant (<50% stenosis) CAD. Patients with diabetes, chronic heart failure, chronic kidney disease, and so on were excluded from the study.
Results:
Patients without CAD had higher Cys-C levels compared with those with CAD (1338.96±396.71 vs. 853.69±406.72 ng/ml, P<0.001). However, the PTX-3 level was inversely lower in patients without CAD (110.40±48.10 vs. 149.46±49.44 pg/ml, P=0.001). The Cys-C level was found to be 677.11±335.56, 1024.18±401.21, and 1338.96±396.71 ng/ml in patients with significant CAD and nonsignificant CAD, and healthy individuals, respectively (P<0.001). The PTX-3 level was inversely reduced in these groups: 168.43±49.09, 131.14±43.10, and 110.40±48.10 pg/ml, respectively (P<0.001).
Conclusion:
We observed that the levels of Cys-C and PTX-3 were inversely varied in the same study groups. These parameters may aid detection of the presence or identification of the severity of CAD when used in combination. Determinative values could exactly be described in the large study groups.
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