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Updated: Apr 27, 2026
Viability Assays for Cells in Culture
Published on: January 20, 2014
Stem cells, immortalized cells and primary cells in ADMET assays
1Department of Metabolism and Pharmacokinetics, Pharmaceutical Candidate Optimization, Bristol Myers Squibb Co., 5 Research Parkway, Wallingford, CT 06492, USA.
Abstract:
Cell-based assays are beginning to replace traditional absorption, distribution, metabolism, elimination and toxicology (ADMET) models employing subcellular fractions in high throughput drug discovery screening and drug development where drugs are characterized and predictions are formulated to forecast in vivo biological outcomes. Significant and continuing advances in stem cell research, new immortalized cell lines and our enhanced ability to predict outcomes from primary cells have increased the ability to employ cell-based assays to study ADMET properties of new drugs.:
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