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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
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Differences in initial immunoprofiles between recurrent and nonrecurrent chronic rhinosinusitis with nasal polyps
Thibaut Van Zele1, Gabriele Holtappels, Philippe Gevaert
1Upper Airway Research Laboratory, and Department of Otorhinolaryngology, Ghent University, Belgium.
American Journal of Rhinology & Allergy
|July 2, 2014
Summary
Recurrent chronic rhinosinusitis with nasal polyps (CRSwNPs) shows distinct inflammatory patterns. Higher interferon-gamma (IFN-γ) levels in non-recurrent CRSwNPs may predict successful surgery outcomes.
Area of Science:
- Immunology
- Otolaryngology
- Pathology
Background:
- Surgery for chronic rhinosinusitis with nasal polyps (CRSwNPs) frequently fails due to disease recurrence.
- The role of specific cytokine profiles in predicting CRSwNPs recurrence after functional endoscopic sinus surgery (FESS) remains unclear.
Purpose of the Study:
- To investigate and compare the cytokine profiles of CRSwNPs in patients undergoing their first FESS versus those with recurrent disease.
- To identify potential biomarkers for predicting recurrence after FESS.
Main Methods:
- Tissue samples from 21 non-recurrent and 15 recurrent CRSwNP patients were analyzed.
- Levels of various cytokines including Interleukin (IL)-1beta, IgE, IL-5, Interferon (IFN) gamma, IL-6, IL-17, Transforming Growth Factor (TGF) beta1, and myeloperoxidase were measured.
Main Results:
- Recurrent CRSwNPs showed significantly higher levels of IgE, specific IgE to Staphylococcus aureus enterotoxin, eosinophilic cationic protein (ECP), and IL-5 compared to non-recurrent cases.
- Non-recurrent CRSwNPs had significantly higher IFN-gamma levels, which were associated with a reduced odds ratio for recurrence (0.029).
- Asthma and aspirin intolerance were more prevalent in the recurrent CRSwNP group.
Conclusions:
- Distinct inflammatory patterns differentiate non-recurrent and recurrent CRSwNPs requiring revision surgery.
- Non-recurrent CRSwNPs exhibit a mixed T helper (Th) cytokine pattern with higher IFN-gamma and lower IgE/IL-5 levels.
- Recurrent CRSwNPs are characterized by a predominant Th2-type inflammation with elevated IgE, ECP, and IL-5.
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