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Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography
Published on: May 26, 2015
Development and validation of novel imaging technologies to assist translational studies in atherosclerosis
Robbert-Jan J H M Miserus1, Sylvia Heeneman2, Jos M A van Engelshoven1
1University of Maastricht, Department of Radiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, The Netherlands.
Abstract:
In the past decade, significant progress has been made to visualize atherosclerotic disease. Until recently, imaging technologies mainly focused on lumen and vessel wall visualization. Current advances and knowledge on the molecular mechanisms of initiation and progression of atherosclerosis has emphasized the need for imaging technologies and probes that can image function and biology rather than anatomy. This field of molecular imaging is now in rapid development with new imaging agents that aim at visualizing processes involved in atherosclerosis such as inflammation, macrophage activation, protease activity, angiogenesis, apoptosis, lipid accumulation and thrombus formation.:
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