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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development
Jan van der Greef1, Aram Adourian2, Pieter Muntendam2
1TNO Systems Biology, Netherlands Organization for Applied Scientific Research, Zeist, Netherlands.
Abstract:
Too few drug discovery projects generate a marketed drug product, often because preclinical studies fail to predict the clinical experience with a drug candidate. Improving the success of preclinical-to-clinical translation is of paramount importance in optimizing the pharmaceutical value chain. Here, we advance the case for a molecular systems approach to crossing the preclinical-to-clinical translational chasm and for metabolomic analysis of readily accessible bodyfluids as a key technology in translational activities.:
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