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Mitochondrial Membranes01:45

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A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
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Updated: Apr 27, 2026

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
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Mitochondrial dysfunction: a neglected component of skin diseases.

René G Feichtinger1, Wolfgang Sperl, Johann W Bauer

  • 1Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.

Experimental Dermatology
|July 2, 2014
PubMed
Summary

Mitochondrial dysfunction is common in skin diseases, affecting tissue health and contributing to aging. Addressing mitochondrial issues offers new therapeutic avenues for various skin conditions.

Keywords:
OXPHOSenergy metabolismmitochondriarespiratory chainskin

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Area of Science:

  • Dermatology
  • Mitochondrial Biology
  • Metabolic Disorders

Background:

  • Aberrant mitochondrial structure and function impact tissue homeostasis and human disorders.
  • Skin manifestations, including hair abnormalities, rashes, and pigmentation changes, occur in 10% of primary mitochondrial disorder patients.
  • Several skin disorders are linked to altered mitochondrial energy metabolism.

Purpose of the Study:

  • To review the contribution of mitochondrial pathology to common and rare skin diseases.
  • To explore the link between skin disorders and primary or secondary mitochondrial pathology.
  • To discuss the role of mitochondrial energy metabolism in dermatological conditions and aging.

Main Methods:

  • Literature review of studies on mitochondrial pathology in skin diseases.
  • Analysis of molecular defects causing dysfunctional mitochondria in skin disorders.
  • Discussion of implications for dermatological treatment and aging skin.

Main Results:

  • A wide array of skin disorders exhibits primary or secondary mitochondrial pathology.
  • Mutations in mitochondrial and nuclear DNA, intermediate filament proteins, and metabolic pathways contribute to mitochondrial dysfunction.
  • Mitochondrial involvement is prevalent in skin diseases.

Conclusions:

  • Improving mitochondrial function may benefit aged skin and serve as adjunctive therapy for certain skin disorders.
  • Understanding mitochondrial energy metabolism provides a new perspective for dermatology and metabolic disease experts.
  • Mitochondrial pathology is a key factor in skin health and disease.