Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.3K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.3K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

14.8K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
14.8K
Genetic Screens02:46

Genetic Screens

4.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
4.6K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

4.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
4.7K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

119
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
119

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"It's an Uncomfortable Subject"-a Qualitative Exploration of the Challenges and Potential Solutions to Depression Screening in Low Back Pain.

Physical therapy·2026
Same author

Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation.

Nature communications·2025
Same author

Depression among people with low back pain: a cross-sectional descriptive survey of Irish musculoskeletal triage physiotherapists' screening and referral practices.

Physiotherapy·2025
Same author

Screening for depression, anxiety, and psychological distress associated with low back pain by musculoskeletal and spinal clinicians. A scoping review.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2025
Same author

Supportive Housing for Sexual and Gender Minority Individuals with Criminal Justice Histories: Challenges and Opportunities Identified by Providers and Clients.

Housing policy debate·2024
Same author

Promoting physical activity in rheumatoid arthritis through a physiotherapist led behaviour change-based intervention (PIPPRA): a feasibility randomised trial.

Rheumatology international·2024
Same journal

Advances in virtual screening.

Drug discovery today. Technologies·2024
Same journal

Integration of virtual and physical screening.

Drug discovery today. Technologies·2024
Same journal

A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development.

Drug discovery today. Technologies·2021
Same journal

Mass spectrometry based approaches and strategies in bioanalysis for qualitative and quantitative analysis of pharmaceutically relevant molecules.

Drug discovery today. Technologies·2021
Same journal

Drug discovery from natural products using affinity selection-mass spectrometry.

Drug discovery today. Technologies·2021
Same journal

Editorial for the role(s) of MS in drug research and development.

Drug discovery today. Technologies·2021
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

22.2K

Model organisms and target discovery.

Marco Muda1, Sean McKenna1

  • 1Serono Reproductive Biology Institute Inc., One Technology Place, Rockland MA 02370, USA.

Drug Discovery Today. Technologies
|July 2, 2014
PubMed
Summary
This summary is machine-generated.

Simple model organisms like yeast, worms, and flies are crucial for identifying new therapeutic targets. These organisms accelerate drug discovery, overcoming limitations of genomic data alone.

More Related Videos

Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery
10:19

Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery

Published on: June 26, 2014

14.1K
A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
07:45

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

20.2K

Related Experiment Videos

Last Updated: Apr 27, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

22.2K
Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery
10:19

Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery

Published on: June 26, 2014

14.1K
A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
07:45

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

20.2K

Area of Science:

  • Biotechnology
  • Genomics
  • Pharmacology

Background:

  • Genomic sequencing projects yield vast data but few novel therapeutic targets.
  • Traditional drug discovery faces challenges in identifying actionable targets from genomic information.

Purpose of the Study:

  • To highlight the role of simple model organisms in identifying and validating novel drug targets.
  • To emphasize the shift in pharmaceutical research towards utilizing model organisms for drug discovery.

Main Methods:

  • Utilizing established model organisms (yeasts, worms, flies, fishes, mice) in research.
  • Leveraging decades of data from basic research in these organisms for drug discovery.

Main Results:

  • Model organisms provide a viable strategy for discovering new therapeutic targets.
  • Pharmaceutical companies are increasingly adopting model organisms in their drug discovery pipelines.

Conclusions:

  • Simple model organisms are essential tools for modern drug discovery.
  • The application of model organisms bridges the gap between genomic information and therapeutic interventions.