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Updated: Apr 27, 2026

Long-term In Vivo Tracking of Inflammatory Cell Dynamics Within Drosophila Pupae
Published on: June 14, 2018
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system
Tatsushi Igaki1, Masayuki Miura2
1Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Yoshida-Konoecho, Sakyo-ku, Kyoto 606-8501, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Basic Research Program, Japan Science and Technology Agency, Chiyoda-ku, Tokyo 102-0075, Japan.
Abstract:
The TNF and TNFR superfamilies of proteins are conserved throughout evolution. The first invertebrate orthologs of TNF and TNFR, Eiger and Wengen, were identified in Drosophila, which enabled us to take advantage of its powerful genetics. Indeed, genetic studies on Eiger in the last decade have discovered their signaling mechanisms through activation of the JNK pathway and unveiled the role of Eiger-JNK signaling in a variety of cellular and tissue processes such as cell death, cell proliferation, tissue growth regulation, host defense, pain sensitization, and canalization. In this review, we will describe the in vivo signaling of Eiger and its physiological roles in fly development and homeostasis, and will discuss the evolution of the TNF/TNFR systems.
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