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Updated: Apr 27, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
High-affinity IgE receptor gene polymorphism and allergic rhinitis in a Polish population
Barbara Korzycka-Zaborowska1, Hanna Zielińska-Bliźniewska2, Jarosław Miłoński2
1Department of Alergology and Respiratory Rehabilitation, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland.
Introduction:
The high-affinity IgE receptor (FcɛRIβ subunit int 2) gene polymorphism is a candidate gene in atopic diseases and is associated with atopy. The aim of this biochemical study was to investigate the association of its intronic mutation and allergic rhinitis in a Polish population.
Materials And Methods:
100 atopic patients and 85 controls were included in the study. Polymerase chain reaction-based analysis for FcɛRIβ subunit int 2 gene polymorphism was used for genotyping and detection.
Results:
There was a difference in the frequencies of genotypes of FcɛRIβ subunit int 2 in allergic rhinitis patients and controls. The FcɛRIβ subunit int 2 gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort.
Conclusion:
The results indicate that genetic factors may play an important role in the allergic rhinitis development in the investigated group.
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