Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cohesins02:20

Cohesins

4.5K
Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of...
4.5K
Cohesins02:20

Cohesins

2.1K
2.1K
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

3.6K
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
3.6K
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

2.3K
2.3K
Condensins02:15

Condensins

3.7K
Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
3.7K
Condensins02:15

Condensins

1.8K
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of histone chaperone MCM2 as a key regulator in arsenic-induced depletion of H3.3 at genomic loci.

Toxicology and applied pharmacology·2023
Same author

Microfluidic isolation of aptamers with affinity towards multiple myeloma monoclonal immunoglobulins.

Biomedical microdevices·2022
Same author

Doxycycline promotes proteasome fitness in the central nervous system.

Scientific reports·2021
Same author

Generation and Analysis of dsDNA Breaks for Checkpoint and Repair Studies in Fission Yeast.

Methods in molecular biology (Clifton, N.J.)·2021
Same author

Personalized immunoglobulin aptamers for detection of multiple myeloma minimal residual disease in serum.

Communications biology·2020
Same author

XPG-related nucleases are hierarchically recruited for double-stranded rDNA break resection.

The Journal of biological chemistry·2019
Same journal

40 years of CENP-A: the foundation of a new era of centromere biology.

Chromosoma·2025
Same journal

Sustainable integrative cell biology: CENP-C is guilty by association.

Chromosoma·2025
Same journal

Molecular and bioinformatics analysis of long non-coding RNAs in cervical cancer.

Chromosoma·2025
Same journal

The synaptonemal complex component corolla regulates meiotic crossover formation in Drosophila melanogaster.

Chromosoma·2025
Same journal

Phosphorylation as a regulatory mechanism of HP1 protein multifunctionality.

Chromosoma·2025
Same journal

A tribute to Chromosoma, Biology of the Nucleus.

Chromosoma·2025
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline
09:14

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline

Published on: September 13, 2022

4.4K

Functional interplay between cohesin and Smc5/6 complexes.

Claudia Tapia-Alveal1, Su-Jiun Lin, Matthew J O'Connell

  • 1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, Box 1130, New York, NY, 10029, USA.

Chromosoma
|July 2, 2014
PubMed
Summary
This summary is machine-generated.

Structural Maintenance of Chromosome (SMC) complexes, including cohesin and Smc5/6, are crucial for chromosome dynamics. These proteins cooperate to manage chromosome structure throughout interphase and enable segregation during cell division.

More Related Videos

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

11.2K
Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
10:11

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level

Published on: July 26, 2024

1.6K

Related Experiment Videos

Last Updated: Apr 27, 2026

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline
09:14

Super-Resolution Microscopy of the Synaptonemal Complex Within the Caenorhabditis elegans Germline

Published on: September 13, 2022

4.4K
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

11.2K
Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
10:11

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level

Published on: July 26, 2024

1.6K

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Chromosomes undergo significant structural changes during the cell cycle, including replication, transcription, repair, condensation, and segregation.
  • Structural Maintenance of Chromosome (SMC) complexes, such as cohesin, condensin, and Smc5/6, are key regulators of these chromosomal processes.
  • While cohesin is known for sister chromatid cohesion and condensin for chromosome condensation, the precise roles of Smc5/6 have been primarily linked to DNA repair.

Purpose of the Study:

  • To explore the broader functions of cohesin and Smc5/6 beyond their established roles.
  • To investigate the cooperative interactions between SMC complexes in controlling chromosome dynamics.
  • To understand how SMC complexes regulate chromosome structure throughout interphase and facilitate segregation.

Main Methods:

  • The study focuses on the functional analysis of cohesin and Smc5/6.
  • Investigates the dynamic interactions of SMC complexes with chromosomes.
  • Examines the regulation of chromosome structure and dynamics during the cell cycle.

Main Results:

  • The functional scope of cohesin and Smc5/6 extends beyond sister chromatid cohesion and DNA repair.
  • These SMC complexes interact and cooperate to govern chromosome dynamics during interphase.
  • SMC complexes dynamically regulate chromosome structure, releasing sister chromatids for segregation at anaphase.

Conclusions:

  • Cohesin and Smc5/6 play critical, interconnected roles in managing chromosome dynamics throughout the cell cycle.
  • SMC complexes are essential for maintaining chromosome integrity and ensuring accurate cell division.
  • The dynamic regulation of chromosome structure by SMC complexes is fundamental to cellular processes.