Global gene expression analysis in the zebrafish: the challenge and the promise

Microarray technology allows the simultaneous changes in multiple gene expression to be determined as part of a drug discovery platform, or to understand the biological mechanisms of disease. In terms of both of these objectives, those studying the zebrafish as a complement to mouse-based research are only now able to entertain the construction of microarrays due to recent progress in sequencing the zebrafish genome. The advantage of the late entry of zebrafish to the microarray field offers the means of immediately adopting best practice, while also appreciating that what is currently on offer can be improved.: