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Predicting the intestinal absorption potential of hits and leads
M D Hämäläinen1, A Frostell-Karlsson1
1Biacore AB, Rapsgatan 7, S-75450 Uppsala, Sweden.
Abstract:
Today's pharma environment requires rapid and reliable methods of screening drug leads for intestinal permeability potential in the early stages of drug discovery. Techniques using excised tissues, Caco-2 cells, artificial membranes, 'in silico' techniques and surface plasmon resonance (SPR)-based biosensors are critically examined in terms of their reliability, measurement criteria, throughput and utility in identifying potentially successful or unsuccessful drug molecules.:
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